Reynolds Cardiovascular Risk Score

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Clinical Use

Predict 10-year cardiovascular risk in healthy and non-diabetic individuals 45 years or older

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The Reynolds Risk Score was developed and validated in 2007 using data from 24,558 initially healthy American women 45 years or older.1 Subjects were followed over a ten-year period for the development of heart attack, stroke, angioplasty, coronary artery bypass surgery, or death related to heart disease.

Subsequently, the Reynolds Risk Score for men was similarly developed in 2008 using data from 10,724 non-diabetic American men.2 Participants were followed over a ten-year period for the development of the same cardiovascular endpoints.

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Computational Formulas

The Reynolds Risk Score (Model B) for Women

10-year cardiovascular disease risk (%) = [1 − 0.98634(exp[B − 22.325])] × 100% where

B = 0.0799 × age + 3.137 × natural logarithm (systolic blood pressure) + 0.180 × natural logarithm (high-sensitivity C-reactive protein) + 1.382 × natural logarithm (total cholesterol) −1.172 × natural logarithm (high-density lipoprotein cholesterol) + 0.134 × hemoglobin A1c (%) (if diabetic) + 0.818 (if current smoker) + 0.438 (if family history of premature myocardial infarction)

The Reynolds Risk Score for Men

10-year cardiovascular disease risk (%) = [1 – 0.8990 (exp[B-33.097])] x 100% where

B = 4.385 x natural logarithm(age) + 2.607 x natural logarithm(systolic blood pressure) + 0.963 x natural logarithm(total cholesterol) – 0.772 x natural logarithm(high-density lipoprotein cholesterol) + 0.405 (if current smoker) + 0.102 x natural logarithm(high-sensitivity C-reactive protein) + 0.541 (if parental history of premature myocardial infarction)


1 Ridker PM, Buring JE, Rifai N, Cook NR. Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: The Reynolds Risk Score. JAMA 2007;297:611-619 Full Text
2 Ridker PM, Paynter NP, Rifai N, Gaziano JM, Cook NR. C-reactive protein and parental history improve global cardiovascular risk prediction: The Reynolds Risk Score for Men. Circulation. 2008 Nov 25;118(22):2243-51 Full Text


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Developer: Sirikarn Napan, MD, FACC